Tahedl M, Siah WF, Lope J, Hengeveld JC, Doherty MA, McLaughlin RL, Hardiman O, Tan EL, Toomey A, Kleinerova J, Bede P. Neurotransmitter-Defined Degeneration Patterns in Sporadic and C9orf72-Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems-Implications for Therapy Development. Ann Neurol. 2026 Jul 21. doi: 10.1002/ana.78316. Online ahead of print. PMID: 42479906
Kleinerova J, Tully J, Lope J, Tan EL, Toomey A, Siah WF, Bede P. Driving with Motor Neuron Disease: Disease-Specific Considerations, Multi-Domain Assessments and Support Strategies. Brain Sci. 2026 Apr 10;16(4):408. doi: 10.3390/brainsci16040408. PMID: 42041816
Kleinerova J, Tahedl M, Finegan E, Siah WF, Hengeveld JC, Doherty MA, Hardiman O, McLaughlin RL, Hutchinson S, Tan EL, Bede P. Neuroimaging confirms selective cerebral involvement in primary lateral sclerosis and predilection to brain regions with high metabolic activity. Rev Neurol (Paris). 2026 Mar 31:S0035-3787(26)00495-9. doi: 10.1016/j.neurol.2026.03.003. Online ahead of print. PMID: 41925483
Preuilh A, Lackmy-Vallée A, Béranger B, Galléa C, Bede P, Querin G, Pradat PF, Pélégrini-Issac M, Marchand-Pauvert V. Impaired kinesthesia and cerebral integration during tendon vibration in amyotrophic lateral sclerosis. Clin Neurophysiol. 2026 Mar 27;187:2111864. doi: 10.1016/j.clinph.2026.2111864. Online ahead of print. PMID: 41921453
Toomey A, Kleinerova J, Tan EL, Siah WF, Bede P. Muscle MRI and Muscle Ultrasound Applications in MND/ALS: Academic Insights and Clinical Opportunities. Eur J Neurol. 2026 Mar;33(3):e70582. doi: 10.1111/ene.70582. PMID: 41872984
Tahedl M, Kleinerova J, McKenna MC, Siah WF, Hardiman O, Hengeveld JC, Doherty MA, McLaughlin RL, Tan EL, Hutchinson S, Bede P. Putative mitochondrial components of frontotemporal lobar degeneration: topological correlations between mitochondrial density and atrophy in FTLD/FTD phenotypes. J Neurol. 2025 Dec 8;273(1):11. doi: 10.1007/s00415-025-13552-9. PMID: 41354869
Tahedl M, Siah WF, Karavasilis E, Hengeveld JC, Doherty MA, McLaughlin RL, Hardiman O, Tan EL, Christidi F, Kleinerova J, Bede P. Anatomical Associations Between Focal Mitochondrial Metabolism and Patterns of Neurodegeneration in Amyotrophic Lateral Sclerosis. Ann Neurol. 2025 Nov 21. doi: 10.1002/ana.78099. Online ahead of print. PMID: 41267644
Bede P, Siah WF, Kassubek J. Machine-Learning Applications in Frontotemporal Dementia: Challenges, Prospects and Viable Clinical Applications. Eur J Neurol. 2025 Sep;32(9):e70319. doi: 10.1111/ene.70319. PMID: 40923185
Mehra P, Metzger M, Bista S, Giglia ER, Plaitano S, Nash L, Mac Domhnaill É, Mitchell M, Khatabi A, Bede P, Lowery M, Muthuraman M, Hardiman O, Nasseroleslami B. SC10X/U: A high-density electrode system for standardised surface recording of neural activity of the cervical spinal cord. Clin Neurophysiol. 2025 Sep;177:2110824. doi: 10.1016/j.clinph.2025.2110824. Epub 2025 Jun 28. PMID: 40618473
Scirocco E, Allen MD, Giacomelli E, Ajroud-Driss S, Andrews J, Banack S, Bede P, Benatar M, Cheung K, Corcia P, de Carvalho M, Elman L, Fink JK, Genge A, Hardiman O, Harms M, Heitzman D, Jang G, Kano O, Kiernan MC, Lee I, Ludolph A, Mehta P, Ozdinler H, Rezania K, Schito P, Sherman AV, Silani V, Sorenson E, Turner MR, Van Den Berg L, Mitsumoto H, Paganoni S. Toward therapeutic trials in primary lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2025 Nov;26(7-8):623-630. doi: 10.1080/21678421.2025.2527123. Epub 2025 Jul 6. PMID: 40618376
O’Doherty L, White A, Almajrafi A, Fennessy A, Heekin A, Bede P, Crowley B, Nabarro L, Nolder D, Rogers C, Moran C, Beausang A, Keane S, Cruz M, Devitt E, Bergin C. Case Report: Reactivation of Chagas disease in a patient with advanced HIV 15 Years after migration. Frontiers in Tropical Diseases 2025, Volume 6 – 2025, doi:10.3389/fitd.2025.1588423.
Li Hi Shing S, Tan EL, Bede P. Post-poliomyelitis syndrome (PPS) (Book Chapter) MARTIN MÜCKE, RUPERT CONRAD (EDITORS) Clinical Syndromes, 1. Edition / Die Klinischen Syndrome, Band 1 Krankheitsbilder, ISBN: 978-3-437-15042-5 / Die Klinischen Syndrome, Band 2 Symptome ISBN: 978-3-437-15043-2
Kleinerova J, Querin G, Pradat PF, Siah WF, Bede P. New developments in imaging in ALS. J Neurol. 2025 May 12;272(6):392. doi: 10.1007/s00415-025-13143-8. PMID: 40353906
Tahedl M, Kleinerova J, Doherty MA, Hengeveld JC, McLaughlin RL, Hardiman O, Tan EL, Bede P. Progressive Thalamo-Cortical Disconnection in Amyotrophic Lateral Sclerosis Genotypes: Structural Degeneration and Network Dysfunction of Thalamus-Relayed Circuits. Eur J Neurol. 2025 May;32(5):e70146. doi: 10.1111/ene.70146. PMID: 40346885
Kleinerova J, Tan EL, Delaney S, Smyth M, Bede P. Advances and research priorities in the respiratory management of ALS: Historical perspectives and new technologies. Rev Neurol (Paris). 2025 May 5:S0035-3787(25)00517-X. doi: 10.1016/j.neurol.2025.04.008. Online ahead of print. PMID: 40328546
Wolmer PS, de Borba FC, de Rezende TJR, González-Salazar C, Pedroso JL, Barsottini OGP, Kleinerova J, Bede P, Marques W Jr, França MC Jr. Distinct patterns of cerebral and spinal pathology along the spectrum of ATXN2-related disorders. J Neurol. 2025 Apr 9;272(5):330. doi: 10.1007/s00415-025-13037-9. PMID: 40204975
Kleinerova J, Chipika RH, Tan EL, Yunusova Y, Marchand-Pauvert V, Kassubek J, Pradat PF, Bede P. Sensory Dysfunction in ALS and Other Motor Neuron Diseases: Clinical Relevance, Histopathology, Neurophysiology, and Insights from Neuroimaging. Biomedicines. 2025 Feb 22;13(3):559. doi: 10.3390/biomedicines13030559. PMID: 40149536
Kleinerova J, Tahedl M, McKenna MC, Garcia-Gallardo A, Hutchinson S, Hardiman O, Raoul C, Ango F, Schneider B, Pradat PF, Tan EL, Bede P. Cerebellar dysfunction in frontotemporal dementia: intra-cerebellar pathology and cerebellar network degeneration. J Neurol. 2025 Mar 25;272(4):289. doi: 10.1007/s00415-025-13046-8. PMID: 40131525
Finegan E, Kleinerova J, Hardiman O, Hutchinson S, Garcia-Gallardo A, Tan EL, Bede P. Pseudobulbar affect: clinical associations, social impact and quality of life implications – Lessons from PLS. J Neurol. 2025 Mar 12;272(4):266. doi: 10.1007/s00415-025-12971-y. PMID: 40072589
McKenna MC, Kleinerova J, Power A, Garcia-Gallardo A, Tan EL, Bede P. Quantitative and Computational Spinal Imaging in Neurodegenerative Conditions and Acquired Spinal Disorders: Academic Advances and Clinical Prospects. Biology (Basel). 2024 Nov 7;13(11):909. doi: 10.3390/biology13110909. PMID: 39596864
Metzger M, Dukic S, McMackin R, Giglia E, Mitchell M, Bista S, Costello E, Peelo C, Tadjine Y, Sirenko V, McManus L, Buxo T, Fasano A, Chipika R, Pinto-Grau M, Schuster C, Heverin M, Coffey A, Broderick M, Iyer PM, Mohr K, Gavin B, Pender N, Bede P, Muthuraman M, Hardiman O, Nasseroleslami B. Distinct Longitudinal Changes in EEG Measures Reflecting Functional Network Disruption in ALS Cognitive Phenotypes. Brain Topogr. 2024 Oct 4;38(1):3. doi: 10.1007/s10548-024-01078-8. PMID: 39367160
Kleinerova J, Garcia-Gallardo A, Tacheva A, Bede P. Subcortical grey matter involvement in ALS and PLS – vulnerable hubs of cortico-cortical and cortico-basal circuits: extrapyramidal, cognitive, bulbar and respiratory correlates. Amyotroph Lateral Scler Frontotemporal Degener. 2024 Sep 24:1-4. doi: 10.1080/21678421.2024.2405130. Online ahead of print. PMID: 39317352
Kleinerova J, McKenna MC, Finnegan M, Tacheva A, Garcia-Gallardo A, Mohammed R, Tan EL, Christidi F, Hardiman O, Hutchinson S, Bede P. Clinical, Cortical, Subcortical, and White Matter Features of Right Temporal Variant FTD. Brain Sci. 2024 Aug 11;14(8):806. doi: 10.3390/brainsci14080806. PMID: 39199498
McKenna MC, Kleinerova J, Tacheva A, Redmond J, Bede P. Teaching NeuroImage: Familial Cerebral Cavernous Malformation in PDCD10 Genotype. Neurology. 2024 Sep 24;103(6):e209799. doi: 10.1212/WNL.0000000000209799. Epub 2024 Aug 22. PMID: 39173099
Christidi F, Kleinerova J, Tan EL, Delaney S, Tacheva A, Hengeveld JC, Doherty MA, McLaughlin RL, Hardiman O, Siah WF, Chang KM, Lope J, Bede P. Limbic Network and Papez Circuit Involvement in ALS: Imaging and Clinical Profiles in GGGGCC Hexanucleotide Carriers in C9orf72 and C9orf72-Negative Patients. Biology (Basel). 2024 Jul 6;13(7):504. doi: 10.3390/biology13070504. PMID: 39056697
Tahedl M, Tan EL, Kleinerova J, Delaney S, Hengeveld JC, Doherty MA, Mclaughlin RL, Pradat PF, Raoul C, Ango F, Hardiman O, Chang KM, Lope J, Bede P. Progressive Cerebrocerebellar Uncoupling in Sporadic and Genetic Forms of Amyotrophic Lateral Sclerosis. Neurology. 2024 Jul 23;103(2):e209623. doi: 10.1212/WNL.0000000000209623. Epub 2024 Jun 20. PMID: 38900989
Argyropoulos GD, Christidi F, Karavasilis E, Bede P, Velonakis G, Antoniou A, Seimenis I, Kelekis N, Smyrnis N, Papakonstantinou O, Efstathopoulos E, Ferentinos P. A Magnetic Resonance Spectroscopy Study on Polarity Subphenotypes in Bipolar Disorder. Diagnostics (Basel). 2024 May 31;14(11):1170. doi: 10.3390/diagnostics14111170. PMID: 38893696
Tan EL, Lope J, Bede P. Harnessing Big Data in Amyotrophic Lateral Sclerosis: Machine Learning Applications for Clinical Practice and Pharmaceutical Trials. J Integr Neurosci. 2024 Mar 18;23(3):58. doi: 10.31083/j.jin2303058. PMID: 38538227
Kleinerova J, Tahedl M, Tan EL, Delaney S, Hengeveld JC, Doherty MA, McLaughlin RL, Hardiman O, Chang KM, Finegan E, Bede P. Supra- and infra-tentorial degeneration patterns in primary lateral sclerosis: a multimodal longitudinal neuroradiology study. J Neurol. 2024 Mar 5. doi: 10.1007/s00415-024-12261-z. Online ahead of print. PMID: 38438819
McKenna MC, O’Connor A, Lockhart A, Bogdanova-Mihaylova P, Brett F, Langan Y, Meaney J, Costigan D, Doherty CP, Bede P, Murphy SM, Hutchinson S. POLR3A-related disorders: expanding the clinical phenotype. J Neurol. 2024 Feb 27. doi: 10.1007/s00415-024-12265-9. Online ahead of print. PMID: 38413463
Dukic S, Fasano A, Coffey A, Buxó T, McMackin R, Chipika R, Heverin M, Bede P, Muthuraman M, Lowery M, Carson RG, Hardiman O, Nasseroleslami B. Electroencephalographic β-band oscillations in the sensorimotor network reflect motor symptom severity in amyotrophic lateral sclerosis. Eur J Neurol. 2024 Jan 18:e16201. doi: 10.1111/ene.16201. Online ahead of print. PMID: 38235854
Tan EL, Lope J, Bede P. Primary lateral sclerosis: more than just an upper motor neuron disease. Neural Regen Res. 2024 Sep 1;19(9):1881-1882. doi: 10.4103/1673-5374.391184. Epub 2023 Dec 21. PMID: 38227508
Metzger M, Dukic S, McMackin R, Giglia E, Mitchell M, Bista S, Costello E, Peelo C, Tadjine Y, Sirenko V, Plaitano S, Coffey A, McManus L, Farnell Sharp A, Mehra P, Heverin M, Bede P, Muthuraman M, Pender N, Hardiman O, Nasseroleslami B. Functional network dynamics revealed by EEG microstates reflect cognitive decline in amyotrophic lateral sclerosis. Hum Brain Mapp. 2023 Dec 13. doi: 10.1002/hbm.26536. Online ahead of print. PMID: 38087950
McMackin R, Bede P, Ingre C, Malaspina A, Hardiman O. Biomarkers in amyotrophic lateral sclerosis: current status and future prospects. Nat Rev Neurol. 2023 Nov 10. doi: 10.1038/s41582-023-00891-2. Online ahead of print. PMID: 37949994
Tan EL, Tahedl M, Lope J, Hengeveld JC, Doherty MA, McLaughlin RL, Hardiman O, Chang KM, Finegan E, Bede P. Language deficits in primary lateral sclerosis: cortical atrophy, white matter degeneration and functional disconnection between cerebral regions. J Neurol. 2023 Sep 27. doi: 10.1007/s00415-023-11994-7. Online ahead of print. PMID: 37759084
Tahedl M, Tan EL, Chipika RH, Lope J, Hengeveld JC, Doherty MA, McLaughlin RL, Hardiman O, Hutchinson S, McKenna MC, Bede P. The involvement of language-associated networks, tracts, and cortical regions in frontotemporal dementia and amyotrophic lateral sclerosis: Structural and functional alterations. Brain Behav. 2023 Sep 11:e3250. doi: 10.1002/brb3.3250. Online ahead of print. PMID: 37694825
Bede P, Pradat PF. The gap between academic advances and therapy development in motor neuron disease. Curr Opin Neurol. 2023 Aug 1;36(4):335-337. doi: 10.1097/WCO.0000000000001179. PMID: 37462047
Bede P, Chipika RH, Tan EL. Imaging extra-motor dysfunction in motor neuron disease: achievements and controversies. Amyotroph Lateral Scler Frontotemporal Degener. 2023 Jul 11:1-3. doi: 10.1080/21678421.2023.2232406. Online ahead of print. PMID: 37431307 No abstract available.
McKenna MC, Hutchinson S, Bede P. Cerebellar involvement in frontotemporal dementia: the infratentorial imaging signatures of FTD phenotypes. J Neurol Neurosurg Psychiatry. 2023;94:A26. (Suppl 1):A26-A26 https://doi.org/10.1136/JNNP-2023-ABN.78
Tahedl M, Tan EL, Siah WF, Hengeveld JC, Doherty MA, McLaughlin RL, Hardiman O, Finegan E, Bede P. Radiological correlates of pseudobulbar affect: Corticobulbar and cerebellar components in primary lateral sclerosis. J Neurol Sci. 2023 Jun 30;451:120726. doi: 10.1016/j.jns.2023.120726. Online ahead of print. PMID: 37421883 Free article.
Tan EL, Bede P, Pradat PF. Promises and pitfalls of imaging-based biomarkers in motor neuron diseases. Curr Opin Neurol. 2023 Jun 7. doi: 10.1097/WCO.0000000000001169. Online ahead of print. PMID: 37382064
McFarlane R, Galvin M, Heverin M, Mac Domhnaill É, Murray D, Meldrum D, Bede P, Bolger A, Hederman L, Impey S, Stephens G, O’Meara C, Wade V, Al Chalabi A, Chiò A, Corcia P, van Damme P, Ingre C, McDermott C, Povedanos M, van den Berg L, Hardiman O. PRECISION ALS-an integrated pan European patient data platform for ALS. Amyotroph Lateral Scler Frontotemporal Degener. 2023 May 23:1-5. doi: 10.1080/21678421.2023.2215838. Online ahead of print. PMID: 37221648
Bede P, Lulé D, Müller HP, Tan EL, Dorst J, Ludolph AC, Kassubek J. Presymptomatic grey matter alterations in ALS kindreds: a computational neuroimaging study of asymptomatic C9orf72 and SOD1 mutation carriers. J Neurol. 2023 May 13. doi: 10.1007/s00415-023-11764-5. Online ahead of print. PMID: 37178170
Tahedl M, Tan EL, Chipika RH, Hengeveld JC, Vajda A, Doherty MA, McLaughlin RL, Siah WF, Hardiman O, Bede P. Brainstem-cortex disconnection in amyotrophic lateral sclerosis: bulbar impairment, genotype associations, asymptomatic changes and biomarker opportunities. J Neurol. 2023 Apr 6. doi: 10.1007/s00415-023-11682-6. Online ahead of print. PMID: 37022479
Quigley S, Yiannakas MC, Bede P, Meaney J, Kearney H. Neuropathologically informed imaging of cortical grey matter lesions in MS – A pilot study. Mult Scler Relat Disord. 2023 Feb 7;71:104555. doi: 10.1016/j.msard.2023.104555. Online ahead of print. PMID: 36870314
Christidi F, Argyropoulos GD, Karavasilis E, Velonakis G, Zouvelou V, Kourtesis P, Pantoleon V, Tan EL, Daponte A, Aristeidou S, Xirou S, Ferentinos P, Evdokimidis I, Rentzos M, Seimenis I, Bede P. Hippocampal Metabolic Alterations in Amyotrophic Lateral Sclerosis: A Magnetic Resonance Spectroscopy Study. Life (Basel). 2023 Feb 17;13(2):571. doi: 10.3390/life13020571. PMID: 36836928
Tahedl M, Tan EL, Shing SLH, Chipika RH, Siah WF, Hengeveld JC, Doherty MA, McLaughlin RL, Hardiman O, Finegan E, Bede P. Not a benign motor neuron disease: longitudinal imaging captures relentless motor connectome disintegration in primary lateral sclerosis. Eur J Neurol. 2023 Feb 5. doi: 10.1111/ene.15725. Online ahead of print. PMID: 36739888
Argyropoulos GD, Christidi F, Karavasilis E, Bede P, Antoniou A, Velonakis G, Seimenis I, Kelekis N, Smyrnis N, Papakonstantinou O, Efstathopoulos E, Ferentinos P. Predominant polarity as a neurobiological specifier in bipolar disorder: Evidence from a multimodal neuroimaging study. Prog Neuropsychopharmacol Biol Psychiatry. 2023 Apr 20;123:110718. doi: 10.1016/j.pnpbp.2023.110718. Epub 2023 Jan 9. PMID: 36634808
McKenna MC, Lope J, Bede P, Tan EL. Thalamic pathology in frontotemporal dementia: Predilection for specific nuclei, phenotype-specific signatures, clinical correlates, and practical relevance. Brain Behav. 2023 Feb;13(2):e2881. doi: 10.1002/brb3.2881. Epub 2023 Jan 7. PMID: 36609810
McKenna MC, Redmond J, Bradley D, Bede P. Teaching NeuroImage: Primary Familial Brain Calcification in SLC20A2 Genotype. Neurology. 2022 Sep 20:10.1212/WNL.0000000000201343. doi: 10.1212/WNL.0000000000201343. Online ahead of print. PMID: 36127139
Mulkerrin G, França MC Jr, Lope J, Tan EL, Bede P. Neuroimaging in hereditary spastic paraplegias: from qualitative cues to precision biomarkers. Expert Rev Mol Diagn. 2022 Aug 30. doi: 10.1080/14737159.2022.2118048. Online ahead of print. PMID: 36042576
McKenna MC, Lope J, Tan EL, Bede P. Pre-symptomatic radiological changes in frontotemporal dementia: propagation characteristics, predictive value and implications for clinical trials. Brain Imaging Behav. 2022 Aug 3. doi: 10.1007/s11682-022-00711-z. Online ahead of print. PMID: 35920960
Theodosiou T, Christidi F, Xirou S, Karavasilis E, Bede P, Papadopoulos C, Argyropoulos GD, Kourtesis P, Pantolewn V, Ferentinos P, Kararizou E, Velonakis G, Zalonis I, Papadimas G. Executive Dysfunction, Social Cognition Impairment, and Gray Matter Pathology in Myotonic Dystrophy Type 2: A Pilot Study. Cogn Behav Neurol. 2022 Jul 21. doi: 10.1097/WNN.0000000000000314. Online ahead of print. PMID: 35867610
Bede P, Chang KM, Tan EL. Machine-learning in Motor Neuron Diseases: Prospects and Pitfalls. Eur J Neurol. 2022 Jun 14. doi: 10.1111/ene.15443. Online ahead of print. PMID: 35699315
Chipika RH, Mulkerrin G, Murad A, Lope J, Hardiman O, Bede P. Alterations in somatosensory, visual and auditory pathways in amyotrophic lateral sclerosis: an under-recognised facet of ALS.J Integr Neurosci. 2022 Apr 27;21(3):88. doi: 10.31083/j.jin2103088. PMID: 35633169
Christidi F, Karavasilis E, Argyropoulos GD, Velonakis G, Zouvelou V, Murad A, Evdokimidis I, Rentzos M, Seimenis I, Bede P. Neurometabolic Alterations in Motor Neuron Disease: Insights from Magnetic Resonance Spectroscopy. J Integr Neurosci. 2022 Apr 24;21(3):87. doi: 10.31083/j.jin2103087. PMID: 35633168
Abidi M, Pradat PF, Termoz N, Couillandre A, Bede P, de Marco G. Motor imagery in amyotrophic lateral Sclerosis: An fMRI study of postural control. Neuroimage Clin. 2022 May 17;35:103051. doi: 10.1016/j.nicl.2022.103051. Online ahead of print. PMID: 35598461
Chipika RH, Mulkerrin G, Pradat PF, Murad A, Ango F, Raoul C, Bede P. Cerebellar pathology in motor neuron disease: neuroplasticity and neurodegeneration. Neural Regen Res. 2022 Nov;17(11):2335-2341. doi: 10.4103/1673-5374.336139. PMID: 35535867
Bede P, Lope J. Biomarker development in Amyotrophic Lateral Sclerosis: challenges and viable strategies. Eur J Neurol. 2022 Apr 25. doi: 10.1111/ene.15372. Online ahead of print. PMID: 35467797
Shing SLH, Murad A, Lope J, Hardiman O, Bede P. Cerebellar remodelling decades after spinal cord insult: neuroplasticity in poliomyelitis survivors. J Integr Neurosci. 2022 Mar 23;21(2):65. doi: 10.31083/j.jin2102065. PMID: 35364653
Bede P, Murad A, Lope J, Hardiman O, Chang KM. Clusters of anatomical disease-burden patterns in ALS: a data-driven approach confirms radiological subtypes. J Neurol. 2022 Mar 25. doi: 10.1007/s00415-022-11081-3. Online ahead of print. PMID: 35333981
McKenna MC, Li Hi Shing S, Murad A, Lope J, Hardiman O, Hutchinson S, Bede P. Focal thalamus pathology in frontotemporal dementia: Phenotype-associated thalamic profiles. J Neurol Sci. 2022 Mar 8;436:120221. doi: 10.1016/j.jns.2022.120221. Online ahead of print. PMID: 35279595
McKenna MC, Murad A, Huynh W, Lope J, Bede P. The changing landscape of neuroimaging in frontotemporal lobar degeneration: from group-level observations to single-subject data interpretation. Expert Rev Neurother. 2022 Feb 28. doi: 10.1080/14737175.2022.2048648. Online ahead of print. PMID: 35227146
Le Gall L, Duddy WJ, Martinat C, Mariot V, Connolly O, Milla V, Anakor E, Ouandaogo ZG, Millecamps S, Lainé J, Vijayakumar UG, Knoblach S, Raoul C, Lucas O, Loeffler JP, Bede P, Behin A, Blasco H, Bruneteau G, Del Mar Amador M, Devos D, Henriques A, Hesters A, Lacomblez L, Laforet P, Langlet T, Leblanc P, Le Forestier N, Maisonobe T, Meininger V, Robelin L, Salachas F, Stojkovic T, Querin G, Dumonceaux J, Butler Browne G, González De Aguilar JL, Duguez S, Pradat PF. Muscle cells of sporadic amyotrophic lateral sclerosis patients secrete neurotoxic vesicles. J Cachexia Sarcopenia Muscle. 2022 Feb 22. doi: 10.1002/jcsm.12945. Online ahead of print. PMID: 35194965
McKenna MC, Tahedl M, Murad A, Lope J, Hardiman O, Hutchinson S, Bede P. White matter microstructure alterations in frontotemporal dementia: Phenotype-associated signatures and single-subject interpretation. Brain Behav. 2022 Jan 24:e2500. doi: 10.1002/brb3.2500. Online ahead of print. PMID: 35072974
Finegan E, Siah WF, Li Hi Shing S, Chipika RH, Hardiman O, Bede P. Cerebellar degeneration in primary lateral sclerosis: an under-recognized facet of PLS. Amyotroph Lateral Scler Frontotemporal Degener. 2022 Jan 6:1-12. doi: 10.1080/21678421.2021.2023188. Online ahead of print. PMID: 34991421
Tahedl M, Li Hi Shing S, Finegan E, Chipika RH, Lope J, Murad A, Hardiman O, Bede P. Imaging data reveal divergent longitudinal trajectories in PLS, ALS and poliomyelitis survivors: Group-level and single-subject traits. Data Brief. 2021 Oct 14;39:107484. doi: 10.1016/j.dib.2021.107484. eCollection 2021 Dec. PMID: 34901337
Li Hi Shing S, Bede P. The neuroradiology of upper motor neuron degeneration: PLS, HSP, ALS. Amyotroph Lateral Scler Frontotemporal Degener. 2021 Dec 13:1-3. doi: 10.1080/21678421.2021.1951293. Online ahead of print. PMID: 34894929
McKenna MC, Tahedl M, Lope J, Chipika RH, Li Hi Shing S, Doherty MA, Hengeveld JC, Vajda A, McLaughlin RL, Hardiman O, Hutchinson S, Bede P. Mapping cortical disease-burden at individual-level in frontotemporal dementia: implications for clinical care and pharmacological trials. Brain Imaging Behav. 2021 Dec 9. doi: 10.1007/s11682-021-00523-7. Online ahead of print. PMID: 34882275
Bede P, Murad A, Lope J, Li Hi Shing S, Finegan E, Chipika RH, Hardiman O, Chang KM. Phenotypic categorisation of individual subjects with motor neuron disease based on radiological disease burden patterns: A machine-learning approach. J Neurol Sci. 2021 Dec 2;432:120079. doi: 10.1016/j.jns.2021.120079. Online ahead of print. PMID: 34875472
Book Chapter: Li Hi Shing S, Lope J, Bede P. The Diagnosis and Management of Motor Neurone Disease. Living with motor neurone disease: a complete guide. 2021 Atrium, Cork University Press. Edited by Dr Marie Murray. ISBN 978-1-78205-483-2
Dukic S, McMackin R, Costello E, Metzger M, Buxo T, Fasano A, Chipika R, Pinto-Grau M, Schuster C, Hammond M, Heverin M, Coffey A, Broderick M, Iyer PM, Mohr K, Gavin B, McLaughlin R, Pender N, Bede P, Muthuraman M, van den Berg L, Hardiman O, Nasseroleslami B. Resting-state EEG reveals four subphenotypes of amyotrophic lateral sclerosis. Brain. 2021 Nov 17:awab322. doi: 10.1093/brain/awab322. Online ahead of print. PMID: 34791079
Eisen A, Bede P. The strength of corticomotoneuronal drive underlies ALS split phenotypes and reflects early upper motor neuron dysfunction. Brain Behav. 2021 Oct 28:e2403. doi: 10.1002/brb3.2403. Online ahead of print. PMID: 34710283
Tahedl M, Li Hi Shing S, Finegan E, Chipika RH, Lope J, Hardiman O, Bede P. Propagation patterns in motor neuron diseases: Individual and phenotype-associated disease-burden trajectories across the UMN-LMN spectrum of MNDs. Neurobiol Aging. 2021 Oct 8;109:78-87. doi: 10.1016/j.neurobiolaging.2021.04.031. Online ahead of print. PMID: 34656922
Bede P, Murad A, Hardiman O. Pathological neural networks and artificial neural networks in ALS: diagnostic classification based on pathognomonic neuroimaging features.J Neurol. 2021 Sep 28. doi: 10.1007/s00415-021-10801-5. Online ahead of print. PMID: 34585269
McKenna MC, Corcia P, Couratier P, Siah WF, Pradat PF, Bede P. Frontotemporal Pathology in Motor Neuron Disease Phenotypes: Insights From Neuroimaging. Front Neurol. 2021 Aug 16;12:723450. doi: 10.3389/fneur.2021.723450. eCollection 2021. PMID: 34484106
Li Hi Shing S, Lope J, Chipika RH, Hardiman O, Bede P. Imaging data indicate cerebral reorganisation in poliomyelitis survivors: Possible compensation for longstanding lower motor neuron pathology. Data Brief. 2021 Aug 21;38:107316. doi: 10.1016/j.dib.2021.107316. eCollection 2021 Oct. PMID: 34485646
Bede P, Siah WF. The diagnostic challenge of Primary Lateral Sclerosis: the integration of clinical, genetic and radiological cues. Eur J Neurol. 2021 Aug 2. doi: 10.1111/ene.15049. Online ahead of print. PMID: 34339556
Tahedl M, Murad A, Lope J, Hardiman O, Bede P. Evaluation and categorisation of individual patients based on white matter profiles: Single-patient diffusion data interpretation in neurodegeneration. J Neurol Sci. 2021 Jul 21;428:117584. doi: 10.1016/j.jns.2021.117584. Online ahead of print. PMID: 34315000
Corcia P, Bede P, Pradat PF, Couratier P, Vucic S, de Carvalho M. Split-hand and split-limb phenomena in amyotrophic lateral sclerosis: pathophysiology, electrophysiology and clinical manifestations. J Neurol Neurosurg Psychiatry. 2021 Jul 20:jnnp-2021-326266. doi: 10.1136/jnnp-2021-326266. Online ahead of print. PMID: 34285065
Bede P, Pradat PF, Lope J, Vourc’h P, Blasco H, Corcia P. Primary Lateral Sclerosis: Clinical, radiological and molecular features. Rev Neurol (Paris). 2021 Jul 6:S0035-3787(21)00592-0. doi: 10.1016/j.neurol.2021.04.008. Online ahead of print. PMID: 34243936
Bede P, Chipika RH, Christidi F, Hengeveld JC, Karavasilis E, Argyropoulos GD, Lope J, Li Hi Shing S, Velonakis G, Dupuis L, Doherty MA, Vajda A, McLaughlin RL, Hardiman O. Genotype-associated cerebellar profiles in ALS: focal cerebellar pathology and cerebro-cerebellar connectivity alterations. J Neurol Neurosurg Psychiatry. 2021 Jun 24:jnnp-2021-326854. doi: 10.1136/jnnp-2021-326854. Online ahead of print. PMID: 34168085
McKenna MC, Chipika RH, Li Hi Shing S, Christidi F, Lope J, Doherty MA, Hengeveld JC, Vajda A, McLaughlin RL, Hardiman O, Hutchinson S, Bede P. Infratentorial pathology in frontotemporal dementia: cerebellar grey and white matter alterations in FTD phenotypes. J Neurol. 2021 May 13. doi: 10.1007/s00415-021-10575-w. Online ahead of print. PMID: 33983551
McMackin R, Dukic S, Costello E, Pinto-Grau M, McManus L, Broderick M, Chipika R, Iyer PM, Heverin M, Bede P, Muthuraman M, Pender N, Hardiman O, Nasseroleslami B. Cognitive network hyperactivation and motor cortex decline correlate with ALS prognosis. Neurobiol Aging. 2021 Mar 10;104:57-70. doi: 10.1016/j.neurobiolaging.2021.03.002. Online ahead of print. PMID: 33964609
Li Hi Shing S, Lope J, McKenna MC, Chipika RH, Hardiman O, Bede P. Increased cerebral integrity metrics in poliomyelitis survivors: putative adaptation to longstanding lower motor neuron degeneration. J Neurol Sci. 2021 May 15;424:117361. doi: 10.1016/j.jns.2021.117361. Epub 2021 Feb 21. PMID: 33773768
Theodosiou T, Christidi F, Xirou S, Bede P, Karavasilis E, Papadopoulos C, Kourtesis P, Pantoleon V, Kararizou E, Papadimas G, Zalonis I. Neuropsychological Assessment Should Always be Considered in Myotonic Dystrophy Type 2. Cogn Behav Neurol. 2021 Mar 3;34(1):1-10. doi: 10.1097/WNN.0000000000000263. PMID: 33652465
Li Hi Shing S, Lope J, Chipika RH, Hardiman O, Bede P. Extra-motor manifestations in post-polio syndrome (PPS): fatigue, cognitive symptoms and radiological features. Neurol Sci. 2021 Feb 26. doi: 10.1007/s10072-021-05130-4. Online ahead of print. PMID: 33635429
Mitsumoto H, Turner MR; all Delegates of the PLS Conference, Ajroud-Driss S, Andres P, Andrews J, Gomez EA, Atehortua JMS, Babu S, Barohn R, Bede P, Benatar M, Chew S, Conwit R, Corcia P, Cudkowicz M, Davis F, Carvalho M, Drory V, Elman L, Factor-Litvak P, Fernandes JAM, Ferrey D, Finegan E, Fink J, Floeter MK, Fournier C, Genge A, Govindarajan R, Granit V, Haase G, Hardiman O, Harms M, Hayat G, Heiman-Patterson T, Hill B, Hübers A, Huey E, Jawdat O, Kano O, Kau K, Kiernan M, Kisanuki Y, Kurent J, Kwan J, Lange D, Ludolph A, Mackenzie I, Manfredi G, Marren D, Morita M, Murphy J, Nations S, Oskarsson B, Paganoni S, Pellerin D, Ravits J, Rezania K, Rouleau G, Scelsa S, Siddique T, Siddique N, Silani V, Simmons Z, Statland J, Traynor B, Blitterswijk MV, Berg LVD, Walk D, Warden D, Wymer J. Preface: promoting research in PLS: current knowledge and future challenges. Amyotroph Lateral Scler Frontotemporal Degener. 2020 Nov;21(sup1):1-2. doi: 10.1080/21678421.2020.1840795. PMID: 33602018
Pioro EP, Turner MR, Bede P. Neuroimaging in primary lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2020 Nov;21(sup1):18-27. doi: 10.1080/21678421.2020.1837176. PMID: 33602015
Costello E, Rooney J, Pinto-Grau M, Burke T, Elamin M, Bede P, McMackin R, Dukic S, Vajda A, Heverin M, Hardiman O, Pender N. Cognitive reserve in amyotrophic lateral sclerosis (ALS): a population-based longitudinal study. J Neurol Neurosurg Psychiatry. 2021 May;92(5):460-465. doi: 10.1136/jnnp-2020-324992. Epub 2021 Feb 9. PMID: 33563807
Finegan E, Shing SLH, Chipika RH, Chang KM, McKenna MC, Doherty MA, Hengeveld JC, Vajda A, Pender N, Donaghy C, Hutchinson S, McLaughlin RL, Hardiman O, Bede P. Extra-motor cerebral changes and manifestations in primary lateral sclerosis. Brain Imaging Behav. 2021 Jan 7. doi: 10.1007/s11682-020-00421-4. Online ahead of print. PMID: 33409820
Tahedl M, Chipika RH, Lope J, Li Hi Shing S, Hardiman O, Bede P. Cortical progression patterns in individual ALS patients across multiple timepoints: a mosaic-based approach for clinical use. J Neurol. 2021 Jan 5. doi: 10.1007/s00415-020-10368-7. Online ahead of print. PMID: 33399966
Li Hi Shing S, McKenna MC, Siah WF, Chipika RH, Hardiman O, Bede P. The imaging signature of C9orf72 hexanucleotide repeat expansions: implications for clinical trials and therapy development. Brain Imaging Behav. 2021 Jan 5. doi: 10.1007/s11682-020-00429-w. Online ahead of print. PMID: 33398779
Querin G, Lenglet T, Debs R, Stojkovic T, Behin A, Salachas F, Le Forestier N, Amador MDM, Bruneteau G, Laforêt P, Blancho S, Marchand-Pauvert V, Bede P, Hogrel JY, Pradat PF. Development of new outcome measures for adult SMA type III and IV: a multimodal longitudinal study. J Neurol. 2021 Jan 2. doi: 10.1007/s00415-020-10332-5. Online ahead of print. PMID: 33388927
The presymptomatic phase of amyotrophic lateral sclerosis: are we merely scratching the surface? Chipika RH, Siah WF, McKenna MC, Li Hi Shing S, Hardiman O, Bede P. J Neurol. 2020 Oct 31. doi: 10.1007/s00415-020-10289-5. Online ahead of print. PMID: 33130950
Finegan E, Siah WF, Shing SLH, Chipika RH, Chang KM, McKenna MC, Doherty MA, Hengeveld JC, Vajda A, Donaghy C, Hutchinson S, McLaughlin RL, Hardiman O, Bede P. Imaging and clinical data indicate considerable disease burden in ‘probable’ PLS: Patients with UMN symptoms for 2-4 years. Data Brief. 2020 Sep 1;32:106247. doi: 10.1016/j.dib.2020.106247. eCollection 2020 Oct. PMID: 32944602
Chipika RH, Siah WF, Shing SLH, Finegan E, McKenna MC, Christidi F, Chang KM, Karavasilis E, Vajda A, Hengeveld JC, Doherty MA, Donaghy C, Hutchinson S, McLaughlin RL, Hardiman O, Bede P. MRI data confirm the selective involvement of thalamic and amygdalar nuclei in amyotrophic lateral sclerosis and primary lateral sclerosis. Data Brief. 2020 Sep 1;32:106246. doi: 10.1016/j.dib.2020.106246. eCollection 2020 Oct. PMID: 32944601
Grollemund V, Le Chat G, Secchi-Buhour MS, Delbot F, Pradat-Peyre JF, Bede P, Pradat PF. Manifold learning for amyotrophic lateral sclerosis functional loss assessment : Development and validation of a prognosis model. J Neurol. 2020 Sep 4. doi: 10.1007/s00415-020-10181-2. Online ahead of print. PMID: 32886252
Querin G, Bede P, Saracino D, Colliot O, Pradat PF, Le Ber I; PREV-DEMALS Study Group. IRM médullaire pour un diagnostic précoce des porteurs asymptomatiques de la mutation C9orf72 : étude longitudinale. Rev Neurol (Paris). 2020 Sep;176S:S38-S39. doi: 10.1016/j.neurol.2020.01.141. PMID: 32906415
Bede P. The diagnosis and management of Motor Neuron Disease. Book chapter Cork University Press edited by Dr Marie Murray 2020 In Press
Bede P, Bogdahn U, Lope J, Chang KM, Xirou S, Christidi F. Neural Regen Res. Degenerative and regenerative processes in amyotrophic lateral sclerosis: motor reserve, adaptation and putative compensatory changes. 2021 Jun;16(6):1208-1209. doi: 10.4103/1673-5374.300440. PMID: 33269779
Abidi M, de Marco G, Grami F, Termoz N, Couillandre A, Querin G, Bede P, Pradat PF. Neural Correlates of Motor Imagery of Gait in Amyotrophic Lateral Sclerosis. J Magn Reson Imaging. 2020 Sep 7. doi: 10.1002/jmri.27335. Online ahead of print. PMID: 32896088
Bede P, Siah WF, McKenna MC, Li Hi Shing S. Consideration of C9orf72-associated ALS-FTD as a neurodevelopmental disorder: insights from neuroimaging. J Neurol Neurosurg Psychiatry. 2020 Aug 27:jnnp-2020-324416. doi: 10.1136/jnnp-2020-324416. Online ahead of print. PMID: 32855286
Grollemund V, Chat GL, Secchi-Buhour MS, Delbot F, Pradat-Peyre JF, Bede P, Pradat PF. Development and validation of a 1-year survival prognosis estimation model for Amyotrophic Lateral Sclerosis using manifold learning algorithm UMAP. Sci Rep. 2020 Aug 7;10(1):13378. doi: 10.1038/s41598-020-70125-8. PMID: 32770027
Finegan E, Li Hi Shing S, Siah WF, Chipika RH, Chang KM, McKenna MC, Doherty MA, Hengeveld JC, Vajda A, Donaghy C, Hutchinson S, McLaughlin RL, Hardiman O, Bede P. Evolving diagnostic criteria in primary lateral sclerosis: The clinical and radiological basis of “probable PLS”. J Neurol Sci. 2020 Jul 24;417:117052. doi: 10.1016/j.jns.2020.117052. Online ahead of print. PMID: 32731060
Chipika RH, Christidi F, Finegan E, Li Hi Shing S, McKenna MC, Chang KM, Karavasilis E, Doherty MA, Hengeveld JC, Vajda A, Pender N, Hutchinson S, Donaghy C, McLaughlin RL, Hardiman O, Bede P. Amygdala pathology in amyotrophic lateral sclerosis and primary lateral sclerosis. J Neurol Sci. 2020 Jul 18:117039. doi: 10.1016/j.jns.2020.117039. Online ahead of print. PMID: 32713609
Argyropoulos GD, Christidi F, Karavasilis E, Velonakis G, Antoniou A, Bede P, Seimenis I, Kelekis N, Douzenis A, Papakonstantinou O, Efstathopoulos E, Ferentinos P. Cerebro-cerebellar white matter connectivity in bipolar disorder and associated polarity subphenotypes. Prog Neuropsychopharmacol Biol Psychiatry. 2020 Jul 22;104:110034. doi: 10.1016/j.pnpbp.2020.110034. Online ahead of print. PMID: 32710925
Chipika RH, Finegan E, Li Hi Shing S, McKenna MC, Christidi F, Chang KM, Doherty MA, Hengeveld JC, Vajda A, Pender N, Hutchinson S, Donaghy C, McLaughlin RL, Hardiman O, Bede P. “Switchboard” malfunction in motor neuron diseases: Selective pathology of thalamic nuclei in amyotrophic lateral sclerosis and primary lateral sclerosis. Neuroimage Clin. 2020 May 30;27:102300. doi: 10.1016/j.nicl.2020.102300. Online ahead of print. PMID: 32554322
Bede P, Chipika RH. Commissural fiber degeneration in motor neuron diseases. Amyotroph Lateral Scler Frontotemporal Degener. 2020 Apr 14:1-3. doi: 10.1080/21678421.2020.1752253. [Epub ahead of print] No abstract available. PMID: 32290711
Pradat PF, Bernard E, Corcia P, Couratier P, Jublanc C, Querin G, Morélot Panzini C, Salachas F, Vial C, Wahbi K, Bede P, Desnuelle C; French Kennedy’s Disease Writing Group. The French national protocol for Kennedy’s disease (SBMA): consensus diagnostic and management recommendations. Orphanet J Rare Dis. 2020 Apr 10;15(1):90. doi: 10.1186/s13023-020-01366-z. PMID: 32276665
Meier JM, van der Burgh HK, Nitert AD, Bede P, de Lange SC, Hardiman O, van den Berg LH, van den Heuvel MP. Connectome-Based Propagation Model in Amyotrophic Lateral Sclerosis. Ann Neurol. 2020 May;87(5):725-738. doi: 10.1002/ana.25706. Epub 2020 Mar 11. PMID: 32072667
Devos D, Moreau C, Kyheng M, Garçon G, Rolland AS, Blasco H, Gelé P, Lenglet TT, Veyrat-Durebex C, Corcia P, Dutheil M, Bede P, Jeromin A, Oeckl P, Otto M, Meininger V, Danel-Brunaud V, Devedjian JC, Duce JA, Pradat PF. Author Correction: A ferroptosis-based panel of prognostic biomarkers for Amyotrophic Lateral Sclerosis. Sci Rep. 2020 Feb 19;10(1):3312. doi: 10.1038/s41598-020-58956-x. PMID: 32075984
Turner MR, Barohn RJ, Corcia P, Fink JK, Harms MB, Kiernan MC, Ravits J, Silani V, Simmons Z, Statland J, van den Berg LH, Ajroud-Driss S, Andrews JA, Babu S, Bede P, Benatar M, Chew S, Conwit R, Cudkowicz M, Carvalho M, Drory VE, Elman L, M Fernandes JA, Ferrey D, Finegan E, Floeter MK, Fournier CN, Govindarajan R, Granit V, Hardiman O, Hayat G, Heiman-Patterson TD, Hübers A, Huey ED, Jawdat O, Kano O, Kisanuki YY, Mackenzie I, Marren D, Morita M, Murphy J, Nations S, Oskarsson B, Paganoni S, Pioro EP, Pullman SL, Rezania K, Rouleau G, Scelsa S, Siddique N, Solano J, Blitterswijk MV, Walk D, Wymer J, Zhao C, Lange D, Mitsumoto H. Primary lateral sclerosis: consensus diagnostic criteria. J Neurol Neurosurg Psychiatry. 2020 Apr;91(4):373-377. doi: 10.1136/jnnp-2019-322541. Epub 2020 Feb 6. PMID: 32029539
Bede P, Chipika RH, Finegan E, Li Hi Shing S, Chang KM, Doherty MA, Hengeveld JC, Vajda A, Hutchinson S, Donaghy C, McLaughlin RL, Hardiman O. Progressive brainstem pathology in motor neuron diseases: Imaging data from amyotrophic lateral sclerosis and primary lateral sclerosis. Data Brief. 2020 Feb 3;29:105229. doi: 10.1016/j.dib.2020.105229. eCollection 2020 Apr. PMID: 32083157
Finegan E, Hi Shing SL, Chipika RH, McKenna MC, Doherty MA, Hengeveld JC, Vajda A, Donaghy C, McLaughlin RL, Hutchinson S, Hardiman O, Bede P. Thalamic, hippocampal and basal ganglia pathology in primary lateral sclerosis and amyotrophic lateral sclerosis: Evidence from quantitative imaging data. Data Brief. 2020 Jan 10;29:105115. doi: 10.1016/j.dib.2020.105115. eCollection 2020 Apr. PMID: 32055654
Christidi F, Karavasilis E, Rentzos M, Velonakis G, Zouvelou V, Xirou S, Argyropoulos G, Papatriantafyllou I, Pantolewn V, Ferentinos P, Kelekis N, Seimenis I, Evdokimidis I, Bede P. Neuroimaging data indicate divergent mesial temporal lobe profiles in amyotrophic lateral sclerosis, Alzheimer’s disease and healthy aging. Data Brief. 2019 Dec 19;28:104991. doi: 10.1016/j.dib.2019.104991. eCollection 2020 Feb. PMID: 31921944
Bede P, Pradat PF. Editorial: Biomarkers and Clinical Indicators in Motor Neuron Disease. Front Neurol. 2019 Dec 12;10:1318. doi: 10.3389/fneur.2019.01318. eCollection 2019. No abstract available. PMID: 31920939
Finegan E, Li Hi Shing S, Chipika RH, Doherty MA, Hengeveld JC, Vajda A, Donaghy C, Pender N, McLaughlin RL, Hardiman O, Bede P. Widespread subcortical grey matter degeneration in primary lateral sclerosis: a multimodal imaging study with genetic profiling. Neuroimage Clin. 2019 Nov 12;24:102089. doi: 10.1016/j.nicl.2019.102089. [Epub ahead of print] PMID: 31795059
Pradat PF, Bede P. “Biomarkers and clinical indicators in Motor neuron disease” 2020, Lausanne: Frontiers Media SA. ISSN 1664-8714, ISBN 978-2-88963-415-6, DOI 10.3389/978-2-88963-415-6 (Book)
Bede P, Chipika RH, Finegan E, Li Hi Shing S, Doherty MA, Hengeveld JC, Vajda A, Hutchinson S, Donaghy C, McLaughlin RL, Hardiman O. Brainstem pathology in amyotrophic lateral sclerosis and primary lateral sclerosis: A longitudinal neuroimaging study. Neuroimage Clin. 2019 Oct 24;24:102054. doi: 10.1016/j.nicl.2019.102054. [Epub ahead of print] PMID: 31711033
Christidi F, Karavasilis E, Rentzos M, Velonakis G, Zouvelou V, Xirou S, Argyropoulos G, Papatriantafyllou I, Pantolewn V, Ferentinos P, Kelekis N, Seimenis I, Evdokimidis I, Bede P. Hippocampal pathology in amyotrophic lateral sclerosis: selective vulnerability of subfields and their associated projections. Neurobiol Aging. 2019 Dec;84:178-188. doi: 10.1016/j.neurobiolaging.2019.07.019. Epub 2019 Sep 23. PMID: 31629116
Marchand-Pauvert V, Peyre I, Lackmy-Vallee A, Querin G, Bede P, Lacomblez L, Debs R, Pradat PF. Absence of hyperexcitability of spinal motoneurons in patients with amyotrophic lateral sclerosis. J Physiol. 2019 Nov;597(22):5445-5467. doi: 10.1113/JP278117. Epub 2019 Oct 26. PMID: 31523813
Li Hi Shing S, Chipika RH, Finegan E, Murray D, Hardiman O, Bede P. Post-polio Syndrome: More Than Just a Lower Motor Neuron Disease. Front Neurol. 2019 Jul 16;10:773. doi: 10.3389/fneur.2019.00773. eCollection 2019. Review. PMID: 31379723
Dukic S, McMackin R, Buxo T, Fasano A, Chipika R, Pinto-Grau M, Costello E, Schuster C, Hammond M, Heverin M, Coffey A, Broderick M, Iyer PM, Mohr K, Gavin B, Pender N, Bede P, Muthuraman M, Lalor EC, Hardiman O, Nasseroleslami B. Patterned functional network disruption in amyotrophic lateral sclerosis. Hum Brain Mapp. 2019 Nov 1;40(16):4827-4842. doi: 10.1002/hbm.24740. Epub 2019 Jul 26. PMID: 31348605
Finegan E, Chipika RH, Li Hi Shing S, Doherty MA, Hengeveld JC, Vajda A, Donaghy C, McLaughlin RL, Pender N, Hardiman O, Bede P. The clinical and radiological profile of primary lateral sclerosis: a population-based study. J Neurol. 2019 Nov;266(11):2718-2733. doi: 10.1007/s00415-019-09473-z. Epub 2019 Jul 19. PMID: 31325016
Abidi M, de Marco G, Couillandre A, Feron M, Mseddi E, Termoz N, Querin G, Pradat PF, Bede P. Adaptive functional reorganization in amyotrophic lateral sclerosis: coexisting degenerative and compensatory changes. Eur J Neurol. 2020 Jan;27(1):121-128. doi: 10.1111/ene.14042. Epub 2019 Aug 13. PMID: 31310452
Bede P. The histological correlates of imaging metrics: postmortem validation of in vivo findings. Amyotroph Lateral Scler Frontotemporal Degener. 2019 Nov;20(7-8):457-460. doi: 10.1080/21678421.2019.1639195. Epub 2019 Jul 11. PMID: 31293187
Querin G, Bede P, El Mendili MM, Li M, Pélégrini-Issac M, Rinaldi D, Catala M, Saracino D, Salachas F, Camuzat A, Marchand-Pauvert V, Cohen-Adad J, Colliot O, Le Ber I, Pradat PF; Predict to Prevent Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Study Group. Presymptomatic spinal cord pathology in c9orf72 mutation carriers: A longitudinal neuroimaging study. Ann Neurol. 2019 Aug;86(2):158-167. doi: 10.1002/ana.25520. Epub 2019 Jun 27. PMID: 31177556
El Mendili MM, Querin G, Bede P, Pradat PF. Spinal Cord Imaging in Amyotrophic Lateral Sclerosis: Historical Concepts-Novel Techniques. Front Neurol. 2019 Apr 12;10:350. doi: 10.3389/fneur.2019.00350. eCollection 2019. PMID: 31031688
Finegan E, Chipika RH, Li Hi Shing S, Hardiman O, Bede P. Pathological Crying and Laughing in Motor Neuron Disease: Pathobiology, Screening, Intervention. Front Neurol. 2019 Mar 21;10:260. doi: 10.3389/fneur.2019.00260. eCollection 2019. PMID: 30949121
Chipika RH, Finegan E, Li Hi Shing S, Hardiman O, Bede P. Tracking a Fast-Moving Disease: Longitudinal Markers, Monitoring, and Clinical Trial Endpoints in ALS. Front Neurol. 2019 Mar 19;10:229. doi: 10.3389/fneur.2019.00229. eCollection 2019. PMID: 30941088
Grollemund V, Pradat PF, Querin G, Delbot F, Le Chat G, Pradat-Peyre JF, Bede P. Machine Learning in Amyotrophic Lateral Sclerosis: Achievements, Pitfalls, and Future Directions. Front Neurosci. 2019 Feb 28;13:135. doi: 10.3389/fnins.2019.00135. eCollection 2019. PMID: 30872992
Yunusova Y, Plowman EK, Green JR, Barnett C, Bede P. Clinical Measures of Bulbar Dysfunction in ALS. Front Neurol. 2019 Feb 19;10:106. doi: 10.3389/fneur.2019.00106. eCollection 2019. PMID: 30837936
Devos D, Moreau C, Kyheng M, Garçon G, Rolland AS, Blasco H, Gelé P, Timothée Lenglet T, Veyrat-Durebex C, Corcia P, Dutheil M, Bede P, Jeromin A, Oeckl P, Otto M, Meninger V, Danel-Brunaud V, Devedjian JC, Duce JA, Pradat PF. A ferroptosis-based panel of prognostic biomarkers for Amyotrophic Lateral Sclerosis. Sci Rep. 2019 Feb 27;9(1):2918. doi: 10.1038/s41598-019-39739-5. PMID: 30814647
McMackin R, Bede P, Pender N, Hardiman O, Nasseroleslami B. Neurophysiological markers of network dysfunction in neurodegenerative diseases. Neuroimage Clin. 2019;22:101706. doi: 10.1016/j.nicl.2019.101706. Epub 2019 Feb 2. PMID: 30738372
McMackin R, Dukic S, Broderick M, Iyer PM, Pinto-Grau M, Mohr K, Chipika R, Coffey A, Buxo T, Schuster C, Gavin B, Heverin M, Bede P, Pender N, Lalor EC, Muthuraman M, Hardiman O, Nasseroleslami B. Dysfunction of attention switching networks in amyotrophic lateral sclerosis. Neuroimage Clin. 2019;22:101707. doi: 10.1016/j.nicl.2019.101707. Epub 2019 Feb 2. PMID: 30735860
Proudfoot M, Bede P, Turner MR. Imaging Cerebral Activity in Amyotrophic Lateral Sclerosis. Front Neurol. 2019 Jan 8;9:1148. doi: 10.3389/fneur.2018.01148. eCollection 2018. Review. PMID: 30671016
Finegan E, Chipika RH, Shing SLH, Hardiman O, Bede P. Primary lateral sclerosis: a distinct entity or part of the ALS spectrum? Amyotroph Lateral Scler Frontotemporal Degener. 2019 May;20(3-4):133-145. doi: 10.1080/21678421.2018.1550518. Epub 2019 Jan 18. PMID: 30654671
Christidi F, Karavasilis E, Rentzos M, Kelekis N, Evdokimidis I, Bede P. Clinical and Radiological Markers of Extra-Motor Deficits in Amyotrophic Lateral Sclerosis. Front Neurol. 2018 Nov 22;9:1005. doi: 10.3389/fneur.2018.01005. eCollection 2018. PMID: 30524366
Querin G, El Mendili MM, Lenglet T, Behin A, Stojkovic T, Salachas F, Devos D, Le Forestier N, Del Mar Amador M, Debs R, Lacomblez L, Meininger V, Bruneteau G, Cohen-Adad J, Lehéricy S, Laforêt P, Blancho S, Benali H, Catala M, Li M, Marchand-Pauvert V, Hogrel JY, Bede P, Pradat PF. The spinal and cerebral profile of adult spinal-muscular atrophy: A multimodal imaging study. Neuroimage Clin. 2019;21:101618. doi: 10.1016/j.nicl.2018.101618. Epub 2018 Nov 28. PMID: 30522974 (Joint Senior Authors)
Klomjai W, Roche N, Lamy JC, Bede P, Giron A, Bussel B, Bensmail D, Katz R, Lackmy-Vallée A. Furosemide Unmasks Inhibitory Dysfunction after Spinal Cord Injury in Humans: Implications for Spasticity. J Neurotrauma. 2019 May 1;36(9):1469-1477. doi: 10.1089/neu.2017.5560. Epub 2018 Dec 19. PMID: 30417726
Querin G, Bede P, Marchand-Pauvert V, Pradat PF. Biomarkers of Spinal and Bulbar Muscle Atrophy (SBMA): A Comprehensive Review. Front Neurol. 2018 Oct 10;9:844. doi: 10.3389/fneur.2018.00844. eCollection 2018. PMID: 30364135
Querin G, Lenglet T, Debs R, Stojkovic T, Behin A, Salachas F, Le Forestier N, Amador MDM, Lacomblez L, Meininger V, Bruneteau G, Laforêt P, Blancho S, Marchand-Pauvert V, Bede P, Hogrel JY, Pradat PF. The motor unit number index (MUNIX) profile of patients with adult spinal muscular atrophy. Clin Neurophysiol. 2018 Nov;129(11):2333-2340. doi: 10.1016/j.clinph.2018.08.025. Epub 2018 Sep 13. PMID: 30248623
Bede P, Finegan E, Chipika RH, Li Hi Shing S, Lambe J, Meaney J, Redmond J. Occulomotor Neural Integrator Dysfunction in Multiple Sclerosis: Insights From Neuroimaging. Front Neurol. 2018 Aug 23;9:691. doi: 10.3389/fneur.2018.00691. eCollection 2018. PMID: 30190700
Christidi F, Karavasilis E, Velonakis G, Ferentinos P, Rentzos M, Kelekis N, Evdokimidis I, Bede P. The Clinical and Radiological Spectrum of Hippocampal Pathology in Amyotrophic Lateral Sclerosis. Front Neurol. 2018 Jul 3;9:523. doi: 10.3389/fneur.2018.00523. eCollection 2018. PMID: 30018591
Feron M, Couillandre A, Mseddi E, Termoz N, Abidi M, Bardinet E, Delgadillo D, Lenglet T, Querin G, Welter ML, Le Forestier N, Salachas F, Bruneteau G, Del Mar Amador M, Debs R, Lacomblez L, Meininger V, Pélégrini-Issac M, Bede P, Pradat PF, de Marco G. Extrapyramidal deficits in ALS: a combined biomechanical and neuroimaging study. J Neurol. 2018 Jul 11. doi: 10.1007/s00415-018-8964-y. [Epub ahead of print] PMID: 29995291
Blasco H, Patin F, Descat A, Garçon G, Corcia P, Gelé P, Lenglet T, Bede P, Meininger V, Devos D, Gossens JF, Pradat PF. A pharmaco-metabolomics approach in a clinical trial of ALS: Identification of predictive markers of progression. PLoS One. 2018 Jun 5;13(6):e0198116. doi: 10.1371/journal.pone.0198116. eCollection 2018. PMID: 29870556
Bede P, Querin G, Pradat PF. The changing landscape of motor neuron disease imaging: the transition from descriptive studies to precision clinical tools. Curr Opin Neurol. 2018 Aug;31(4):431-438. doi: 10.1097/WCO.0000000000000569. PMID: 29750730
Bede P, Omer T, Finegan E, Chipika RH, Iyer PM, Doherty MA, Vajda A, Pender N, McLaughlin RL, Hutchinson S, Hardiman O. Connectivity-based characterisation of subcortical grey matter pathology in frontotemporal dementia and ALS: a multimodal neuroimaging study. Brain Imaging Behav. 2018 Dec;12(6):1696-1707. doi: 10.1007/s11682-018-9837-9. PMID: 29423814
Querin G, El Mendili MM, Bede P, Delphine S, Lenglet T, Marchand-Pauvert V, Pradat PF. Multimodal spinal cord MRI offers accurate diagnostic classification in ALS. J Neurol Neurosurg Psychiatry. 2018 Nov;89(11):1220-1221. doi: 10.1136/jnnp-2017-317214. Epub 2018 Jan 20. PMID: 29353238
Bede P, El-Kininy N, O’Hara F, Menon P, Finegan E, Healy D. ‘Khatatonia’ – cathinone-induced hypertensive encephalopathy. Neth J Med. 2017 Dec;75(10):448-450. PMID: 29256414
Bede P, Hardiman O. Longitudinal structural changes in ALS: a three time-point imaging study of white and gray matter degeneration. Amyotroph Lateral Scler Frontotemporal Degener. 2018 May;19(3-4):232-241. doi: 10.1080/21678421.2017.1407795. Epub 2017 Dec 7. PMID: 29214883
Nasseroleslami B, Dukic S, Broderick M, Mohr K, Schuster C, Gavin B, McLaughlin R, Heverin M, Vajda A, Iyer PM, Pender N, Bede P, Lalor EC, Hardiman O. Characteristic Increases in EEG Connectivity Correlate With Changes of Structural MRI in Amyotrophic Lateral Sclerosis. Cereb Cortex. 2019 Jan 1;29(1):27-41. doi: 10.1093/cercor/bhx301. PMID: 29136131
Bede P, Finegan E. Revisiting the pathoanatomy of pseudobulbar affect: mechanisms beyond corticobulbar dysfunction. Amyotroph Lateral Scler Frontotemporal Degener. 2018 Feb;19(1-2):4-6. doi: 10.1080/21678421.2017.1392578. Epub 2017 Nov 2. PMID: 29092641
Bede P. Deciphering neurodegeneration: A paradigm shift from focality to connectivity. Neurology. 2017 Oct 24;89(17):1758-1759. doi: 10.1212/WNL.0000000000004582. Epub 2017 Sep 27. PMID: 28954879
Bede P, Finegan E, Hardiman O. From pneumomyelography to cord tractography: historical perspectives on spinal imaging. Future Neurol. 2017;12(3):121–124
Iyer PM, Mohr K, Broderick M, Gavin B, Burke T, Bede P, Pinto-Grau M, Pender NP, McLaughlin R, Vajda A, Heverin M, Lalor EC, Hardiman O, Nasseroleslami B. Mismatch Negativity as an Indicator of Cognitive Sub-Domain Dysfunction in Amyotrophic Lateral Sclerosis. Front Neurol. 2017 Aug 15;8:395. doi: 10.3389/fneur.2017.00395. eCollection 2017. PMID: 28861032
Williams J, Mullins G, Delanty N, Bede P, Doherty CP. The spectrum of peri-ictal MRI changes; four illustrative cases. Seizure. 2017 Aug;50:189-193. doi: 10.1016/j.seizure.2017.06.024. Epub 2017 Jul 6. PMID: 28709144
Bede P, Iyer PM, Finegan E, Omer T, Hardiman O. Virtual brain biopsies in amyotrophic lateral sclerosis: Diagnostic classification based on in vivo pathological patterns. Neuroimage Clin. 2017 Jun 9;15:653-658. doi: 10.1016/j.nicl.2017.06.010. eCollection 2017. PMID: 28664036
Williams JA, Bede P, Doherty CP. Seizure. An exploration of the spectrum of peri-ictal MRI change; a comprehensive literature review. 2017 Aug;50:19-32. doi: 10.1016/j.seizure.2017.05.005. Epub 2017 May 31. PMID: 28600921
Omer T, Finegan E, Hutchinson S, Doherty M, Vajda A, McLaughlin RL, Pender N, Hardiman O, Bede P. Neuroimaging patterns along the ALS-FTD spectrum: a multiparametric imaging study. Amyotroph Lateral Scler Frontotemporal Degener. 2017 Nov;18(7-8):611-623. doi: 10.1080/21678421.2017.1332077. Epub 2017 May 31. PMID: 28562080
Burke T, Pinto-Grau M, Lonergan K, Bede P, O’Sullivan M, Heverin M, Vajda A, McLaughlin RL, Pender N, Hardiman O. A Cross-sectional population-based investigation into behavioral change in amyotrophic lateral sclerosis: subphenotypes, staging, cognitive predictors, and survival. Ann Clin Transl Neurol. 2017 Apr 11;4(5):305-317. doi: 10.1002/acn3.407. eCollection 2017 May. PMID: 28491898
Schuster C, Hardiman O, Bede P. Survival prediction in Amyotrophic lateral sclerosis based on MRI measures and clinical characteristics. BMC Neurol. 2017 Apr 17;17(1):73. doi: 10.1186/s12883-017-0854-x. PMID: 28412941
Abkur TM, Bede P. Clinical Reasoning: Reversible gait ataxia: From wheelchair to independent mobility. Neurology. 2017 Apr 11;88(15):e145-e149. doi: 10.1212/WNL.0000000000003815. PMID: 28396457
Burke T, Lonergan K, Pinto-Grau M, Elamin M, Bede P, Madden C, Hardiman O, Pender N. Visual encoding, consolidation, and retrieval in amyotrophic lateral sclerosis: executive function as a mediator, and predictor of performance. Amyotroph Lateral Scler Frontotemporal Degener. 2017 May;18(3-4):193-201. doi: 10.1080/21678421.2016.1272615. PMID: 28084080
Bede P, Lawlor D, Solanki D, Delanty N. Carbapenems and valproate: A consumptive relationship. Epilepsia Open. 2016 Dec 26;2(1):107-111. doi: 10.1002/epi4.12030. eCollection 2017 Mar. PMID: 29750220
Bede P. From qualitative radiological cues to machine learning: MRI-based diagnosis in neurodegeneration. Future Neurology 2017 Jan 20;12(1):5-8 , DOI 10.2217/fnl-2016-0029
Schuster C, Hardiman O, Bede P. Development of an Automated MRI-Based Diagnostic Protocol for Amyotrophic Lateral Sclerosis Using Disease-Specific Pathognomonic Features: A Quantitative Disease-State Classification Study. PLoS One. 2016 Dec 1;11(12):e0167331. doi: 10.1371/journal.pone.0167331. eCollection 2016. PMID: 27907080
Elamin M, Pinto-Grau M, Burke T, Bede P, Rooney J, O’Sullivan M, Lonergan K, Kirby E, Quinlan E, Breen N, Vajda A, Heverin M, Pender N, Hardiman O. Identifying behavioural changes in ALS: Validation of the Beaumont Behavioural Inventory (BBI). Amyotroph Lateral Scler Frontotemporal Degener. 2017 Feb;18(1-2):68-73. doi: 10.1080/21678421.2016.1248976. Epub 2016 Nov 28. PMID: 27894191
Burke T, Pinto-Grau M, Lonergan K, Elamin M, Bede P, Costello E, Hardiman O, Pender N. Measurement of Social Cognition in Amyotrophic Lateral Sclerosis: A Population Based Study.PLoS One. 2016 Aug 24;11(8):e0160850. doi: 10.1371/journal.pone.0160850. eCollection 2016. PMID: 27556398
Neurodegenerative Disorders – A Clinical Guide Second Edition Editors: Hardiman O, Doherty CP, Elamin M, Bede P eBook ISBN978-3-319-23309-3 DOI10.1007/978-3-319-23309-3 Hardcover ISBN978-3-319-23308-6 Springer International Publishing (Book)
Schuster C, Elamin M, Hardiman O, Bede P. The segmental diffusivity profile of ALS-associated white matter degeneration. Eur J Neurol. 2016 Aug;23(8):1361-71. doi: 10.1111/ene.13038.PMID: 27207250
Burke T, Elamin M, Bede P, Pinto-Grau M, Lonergan K, Hardiman O, Pender N. Discordant performance on the ‘Reading the Mind in the Eyes’ Test, based on disease onset in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2016 Oct-Nov;17(7-8):467-472. doi: 10.1080/21678421.2016.1177088. Epub 2016 May 6. PMID: 27152765
Bede P, Iyer PM, Schuster C, Elamin M, McLaughlin RL, Kenna K, Hardiman O. “The selective anatomical vulnerability of ALS – “disease-defining” and “disease-defying” brain regions” Amyotroph Lateral Scler Frontotemporal Degener. 2016 Oct – Nov;17(7-8):561-570. Epub 2016 Apr 18. PMID: 27087114
Müller HP, Turner MR, Grosskreutz J, Abrahams S, Bede P, Govind V, Prudlo J, Ludolph AC, Filippi M, Kassubek J; Neuroimaging Society in ALS (NiSALS) DTI Study Group. A large-scale multicentre cerebral diffusion tensor imaging study in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2016 Jun;87(6):570-9. doi: 10.1136/jnnp-2015-311952. Epub 2016 Jan 8. PMID: 26746186
Machts J, Loewe K, Kaufmann J, Jakubiczka S, Abdulla S, Petri S, Dengler R, Heinze H, Vielhaber S, Schoenfeld M, Bede P. Basal ganglia pathology in ALS is associated with neuropsychological deficits. Neurology. 2015 Oct 13;85(15):1301-9. doi: 10.1212/WNL.0000000000002017. Epub 2015 Sep 18.PMID: 26385880
Rowland L, Bede P, Elamin M, Hardiman O. Medical Mimics of Neurodegenerative Diseases (Book chapter) Neurodegenerative disorders: A clinical guide – Second Edition, Chapter 11, p199-212, ISBN: ISBN 978-3-319-23308-6 Springer 2016. DOI 10.1007/978-3-319-23309-3
Iyer P, Doherty C, Bede P. Imaging biomarkers in neurodegenerative conditions (Book chapter) Neurodegenerative disorders: A clinical guide – Second Edition, Chapter 2, p 13-27, ISBN: ISBN 978-3-319-23308-6 Springer 2016. DOI 10.1007/978-3-319-23309-3
Oliver D, Hardiman O, Maguire S, Borasio GD, Bede P. Palliative care and end of life care (Book chapter) Neurodegenerative disorders: A clinical guide – Second Edition, Chapter 17, p305-319, ISBN: 978-3-319-23308-6 Springer 2016. DOI 10.1007/978-3-319-23309-3
Burke T, Wynne B, O’Brien C, Elamin M, Bede P, Hardiman O, Pender, N. Retrospective Investigations of Practice Effects on Repeated Neuropsychological Measures of Executive Functioning. The Irish Journal of Psychology 2014;35(4): 178-187 doi:10.1080/03033910.2015.1044554
Elamin M, Bede P, Montuschi A, Pender N, Chio A, Hardiman O. Predicting prognosis in amyotrophic lateral sclerosis: a simple algorithm. J Neurol. 2015 Jun;262(6):1447-54. doi: 10.1007/s00415-015-7731-6.PMID: 25860344
Schuster C, Elamin M, Hardiman O, Bede P. Presymptomatic and longitudinal neuroimaging in neurodegeneration: from snapshots to motion picture – a systematic review. J Neurol Neurosurg Psychiatry. 2015 Oct;86(10):1089-96. doi: 10.1136/jnnp-2014-309888. PMID: 25632156
McLaughlin RL, Kenna KP, Vajda A, Bede P, Elamin M, Cronin S, Donaghy CG, Bradley DG, Hardiman O. A second-generation Irish genome-wide association study for amyotrophic lateral sclerosis. Neurobiol Aging. 2015 Feb;36(2):1221.e7-13. doi: 10.1016/j.neurobiolaging.2014.08.030. PMID: 25442119
Bede P, Elamin M, Byrne S, McLaughlin RL, Kenna K, Vajda A, Fagan A, Bradley DG, Hardiman O. Patterns of cerebral and cerebellar white matter degeneration in ALS. J Neurol Neurosurg Psychiatry. 2015 Apr;86(4):468-70. doi: 10.1136/jnnp-2014-308172. PMID: 25053771
Lebouteux MV, Franques J, Guillevin R, Delmont E, Lenglet T, Bede P, Desnuelle C, Pouget J, Pascal-Mousselard H, Pradat PF. Revisiting the spectrum of lower motor neuron diseases with “snake-eyes” appearance in MRI. Eur J Neurol. 2014 Sep;21(9):1233-41. PMID: 24847978
Bede P, Hardiman O. Lessons of ALS imaging: pitfalls, inconsistencies, and future directions – a critical review. Neuroimage Clin. 2014 Feb 27;4:436-443. PMID: 24624329
Byrne S, Heverin M, Bede P, Elamin M, Hardiman O. Fecundity in ALS. Amyotroph Lateral Scler Frontotemporal Degener. 2014 Jun;15(3-4):204-6. doi: 10.3109/21678421.2013.865237. PMID: 24479554
Bede P, Elamin M, Byrne S, Hardiman O. Sexual dimorphism in ALS: exploring gender-specific neuroimaging signatures. Amyotroph Lateral Scler Frontotemporal Degener. 2014 Jun;15(3-4):235-43. doi: 10.3109/21678421.2013.865749. Epub 2013 Dec 18. PMID: 24344910
Bede P, Walsh R, Fagan A, Hardiman O. “Sand-watch” spinal cord – a case of inferior cervical spinal cord atrophy. J Neurol. 2014 Jan;261(1):235-7. PMID: 24281771
Bede P, Hardiman O. Subcortical gray matter structures: a future biomarker for ALS? Future Neurology, 2014 March 9(2):109-111 https://doi.org/10.2217/fnl.14.3
Bede P, Elamin M, Byrne S, McLaughlin R, Kenna K, Vajda A, Pender N, Bradley DG, Hardiman O. Basal ganglia involvement in Amyotrophic Lateral Sclerosis. Neurology, 2013 Dec 10;81(24):2107-15. PMID: 24212388
Byrne S, Heverin M, Elamin M, Bede P, Lynch C, Kenna K, Maclaughlin R, Walsh C, Al Chalabi A, Hardiman O. Aggregation of neurologic and neuropsychiatric disease in ALS kindreds: A population based case controlled cohort study of Familial and Sporadic ALS. Ann Neurol. . 2013 Nov;74(5):699-708. PMID: 23836460
Bede P, Bokde ALW, Byrne S, Elamin M, McLaughlin R, Kenna K, Fagan AJ, Pender N, Bradley DG, Hardiman O. A multiparametric MRI study of ALS stratified for the C9orf72 genotype. Neurology. 2013 Jul 23;81(4):361-9. PMID: 23771489
Elamin M, Bede P, Byrne S, Jordan N, Gallagher L, Wynne B, O’Brien C, Phukan J, Lynch C, Pender N, Hardiman O. Cognitive changes predict functional decline in ALS: a population-based longitudinal study. Neurology. 2013 Apr 23;80(17):1590-7. doi: 10.1212/WNL.0b013e31828f18ac. Epub 2013 Apr 3. PMID: 23553481
Bede P, Bokde AL, Elamin M, Bynre S, McLaughlin RL, Jordan N, Hampel H, Gallagher L, Lynch C, Fagan A, Pender N, Hardiman O. Grey matter correlates of clinical variables in Amyotrophic Lateral Sclerosis– a neuroimaging study of ALS motor phenotype heterogeneity and cortical focality. J Neurol Neurosurg Psychiatry. 2013 Jul;84(7):766-73. PMID: 23085933
Turner MR, Agosta F, Bede P, Govind V, Lule D, Verstraete E. Neuroimaging in amyotrophic lateral sclerosis. Biomark Med. 2012 Jun;6(3):319-37. PMID:22731907
Byrne S, Elamin M, Bede P, Hardiman O. Absence of consensus in diagnostic criteria for familial neurodegenerative diseases. J Neurol Neurosurg Psychiatry. 2012 Apr;83(4):365-7. PMID:22399794
Bede P, Bokde AL, Byrne S, Elamin M, Fagan AJ, Hardiman O. Spinal cord markers in ALS: Diagnostic and biomarker considerations. Amyotroph Lateral Scler. 2012 Sep;13(5):407-15. PMID: 22329869
Byrne S, Elamin M, Bede P, Shatunov A, Walsh C, Corr B, Heverin M, Jordan N, Kenna K, Lynch C, McLaughlin RL, Iyer PM, O’Brien C, Phukan J, Wynne B, Bokde AL, Bradley DG, Pender N, Al-Chalabi A, Hardiman O. Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis carrying a C9orf72 repeat expansion: a population-based cohort study. Lancet Neurol. 2012 Mar;11(3):232-40. PMID: 22305801
Bede P, Oliver D, Stodart J, van den Berg L, Simmons Z, Brannagáin DÓ, Borasio GD, Hardiman O. Palliative care in amyotrophic lateral sclerosis: a review of current international guidelines and initiatives. BMJ Support Palliat Care. 2011 Dec;1(3):343-8. PMID: 24653482
Geser F, O’Dwyer L, Hardiman O, Bede P, Bokde AL, Prvulovic D, Trojanowski JQ, Hampel H. On the development of markers for pathological TDP-43 in amyotrophic lateral sclerosis with and without dementia. Prog Neurobiol. 2011 Dec;95(4):649-62. PMID: 21911035
Phukan J, Elamin M, Bede P, Jordan N, Gallagher L, Byrne S, Lynch C, Pender N, Hardiman O. The syndrome of cognitive impairment in amyotrophic lateral sclerosis: a population-based study. J Neurol Neurosurg Psychiatry. 2012 Jan;83(1):102-8.PMID: 21836033
Turner MR, Grosskreutz J, Kassubek J, Abrahams S, Agosta F, Benatar M, Filippi M, Goldstein LH, van den Heuvel M, Kalra S, Lulé D, Mohammadi B, NISALS-members: Atassi N, Bede P, Benali H, Benatar M, Enzinger C, Gaser C, Müller HP, Orrell R, Pradat PF, Prudlo J, Ropele S, Sharma R, Silani V, Simmons A, Smith S, Swain L, Teipel S, Toosy A, Tsermentseli S, Van Damme P, Verstraete E, Welsh R, WittstockM. Towards a neuroimaging biomarker for amyotrophic lateral sclerosis. Lancet Neurol. Lancet Neurol. 2011 May;10(5):400-3. PMID:21511189
Bede P, Bokde AL, Byrne SC, Elamin M, Walsh RJ, Hardiman O. Waterskier’s Hirayama syndrome. J Neurol. 2011 Nov;258(11):2078-9. PMID:21503827
Elamin M, Phukan J, Bede P, Jordan N, Byrne S, Pender N, Hardiman O. Executive dysfunction is a negative prognostic indicator in patients with ALS without dementia. Neurology. 2011 Apr 5;76(14):1263-9. PMID:21464431
Bede P, Oliver D, Stodart J, van den Berg L, Simmons Z, O Brannagáin D, Borasio GD, Hardiman O. Palliative care in amyotrophic lateral sclerosis: a review of current international guidelines. J Neurol Neurosurg Psychiatry. 2011 Apr;82(4):413-8. PMID:21297150
Byrne S, Bede P, Elamin M, Kenna K, Lynch C, McLaughlin R, Hardiman O. Proposed criteria for familial amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2011 May;12(3):157-9. PMID: 21208036
Byrne S, Walsh C, Lynch C, Bede P, Elamin M, Kenna K, McLaughlin R, Hardiman O. Rate of familial amyotrophic lateral sclerosis: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2011 Jun;82(6):623-7. PMID: 21047878
Bede P, O Brannagáin D, Lorenzl S, Oliver DJ, Hardiman O. (2011) Symptomatic Management and Palliative Care in Neurodegenerative Disease (Book chapter NEURODEGENERATIVE DISORDERS: A CLINICAL GUIDE, ISBN: 978-1-84996-010-6, 2011) Springer.